Chronic migraine clinical studies
Do you have chronic migraine?
We are looking for participants in a clinical research study evaluating ShiraTronics Migraine Therapy in those living with chronic migraine.
You may be eligible to participate:
- 22 years of age or older
- Migraine for at least 12 months
- Experiencing 15 or more headache days per month
- No prior treatment with a neurostimulator
- No Botox injections for purposes other than managing migraine
within the last 3 months - Additional criteria may apply
Now Enrolling
RELIEV-CM2 Study for Chronic Migraine
United States and Australia
Find study locations
Enrollment Complete
RELIEV-CM Study for Chronic Migraine
2023 Australia
We look forward to sharing our findings at the completion of the study.
What is Neuromodulation?
Neuromodulation therapy delivers mild electrical pulses called stimulation to nerve pathways associated with migraine.
Stimulation is intended to interrupt or change pain signals, potentially decreasing the frequency and/or pain severity associated with migraine attacks.
What does the study involve?
There are 4 phases in the RELIEV-CM2 study.
1. Assessment Phase
Complete a 28-day headache diary to determine if you are a suitable candidate for the study.
2: Trial Phase
Undergo a short procedure where temporary leads will be inserted beneath the skin near targeted nerves in the head.
You'll be able to try the therapy to determine if a permanent implant is a good choice for you. The trial system is removed after a about a week.
3: Implant Phase
Undergo a minimally invasive surgical procedure where two implantable stimulators and leads will be placed beneath the skin. Once healed, the system will be virtually undetectable to others.
4: Use & Follow Up Phase
Use the therapy 24 hours a day 7 days a week (if desired). You'll charge the system weekly using a handheld charger and headset, and continue to have regular appointments with your study doctor to monitor your progress.